ODCs

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1 OMIM reference -
1 associated gene
23 signs/symptoms

PROTEIN INTERACTIONS: 1

1 OMIM reference -
5 associated genes
No signs/symptoms info

Syndromic X-linked ichthyosis

Juvenile myelomonocytic leukemia


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	STS	(0.63)	CBL

Citations in the biomedical literature:

Syndromic X-linked ichthyosis		Juvenile myelomonocytic leukemia
	Synonym(s): - Syndromic RXLI - Syndromic recessive X-linked ichthyosis		Synonym(s): - Juvenile chronic myelomonocytic leukemia

	Classification (Orphanet): - Rare genetic disease - Rare skin disease		Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease

	Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: childhood Average age of death: - Type of inheritance: x-linked recessive		Epidemiological data: (no data available)

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - 1 MeSH reference: D054429

Syndromic X-linked ichthyosis
	Very frequent - Dry / squaly skin / exfoliation - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Hypohidrosis / decreased sweating / thermoregulation disorder / heat intolerance - Ichthyosis / ichthyosiform dermatitis - Insterstitial / subtelomeric microdeletion / deletion - X-linked recessive inheritance Frequent - Corneal clouding / opacity / vascularisation - Hyperactivity / attention deficit - Intellectual deficit / mental / psychomotor retardation / learning disability - Speech troubles / aphasia / dysphasia / echolalia / mutism / logorrhea / dysprosodia Occasional - Acute leukemia - Agenesis / hypoplasia / aplasia of kidneys - Agyria / micro / pachy / macrogyria / lissencephaly / gyration / neuronal migration defect - Anomalies of the abdominal wall - Anosmia / cacosmia / hypogeusia / hyposmia / olfactory bulb hypoplasia - Autism / autistic disoders - Late puberty / hypogonadism / hypogenitalism - Renal failure - Seizures / epilepsy / absences / spasms / status epilepticus - Short stature / dwarfism / nanism - Stomach / gastric anomaly - Testicular / seminal neoplasm / tumor / carcinoma / cancer (excl. teratoma / germinoma) - Undescended / ectopic testes / cryptorchidia / unfixed testes
Juvenile myelomonocytic leukemia
(no data available)